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Clinical Evidence and Expected Weight Loss Outcomes FDA-Approved Semaglutide Trial Data Clinical trial data for FDA-approved semaglutide provides context for expected outcomes: The STEP 1 trial showed an average weight loss of approximately 14.9% over 68 weeks when combined with reduced-calorie diets and increased physical activity

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The kidneys and liver metabolise the fatty acids, producing ketone bodies as common metabolites [56]