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A phase 2 trial with Retatrutide also noted slight increase in heart rate (around 10bpm) after 24 weeks, but that this increased heart rate subsides over time

Lango R, Smolenski RT, Narkiewicz M, Suchorzewska J, Lysiak-Szydlowska W

It combines GLP-1 and GIP receptor activation (appetite suppression, insulin secretion) with glucagon receptor agonism (thermogenesis, hepatic fat oxidation), producing up to 24% body weight loss at 48 weeks in Phase 2 trials

Most patients notice reduced appetite within 24-72 hours of their first semaglutide injection as GLP-1 receptors activate in the brain and gut

In Kansas, semaglutide injections can be given by professionals with the titles MD, DO, NP, PA, RN, or LP