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Emergency medical services (911) should be contacted for any severe hypoglycemic episode

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For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24

MEDI4166 demonstrates extended glucose control, delays development of diabetes and reduces obesity in rodent models To investigate if the optimised in vivo stability and reduced potency of the MEDI4166 GLP-1 peptide component translates into prolonged glucose control, we compared the impact of MEDI4166 and exendin-4 in fusion with the same antibody partner (Ab#2.1_EX4) on fasting plasma glucose (FPG) levels in moderately hyperglycaemic diet-induced obese (DIO) mice over 21 days (Fig

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