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How representative of a general type 2 diabetes population are patients included in cardiovascular outcome trials with SGLT2 inhibitors

First-Line research protocol: Semaglutide Rise [PMID: 41264827] Laboratory literature summary: First-Line research protocol: Semaglutide Rise

The injectable version aligns exactly with most clinical studies and the regimen employed by Ozempic and Wegovy

More serious considerations include risk of pancreatitis, gallbladder problems, kidney injury (often related to dehydration from gastrointestinal symptoms), and rare cases of medullary thyroid cancer (these medications carry a black box warning for patients with personal or family history of MTC or MEN2 syndrome)

Large human trials and better active surveillance would help answer these questions