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According to the NHS, these neurological symptoms are classic indicators that your body is calling out for more B12

Polex-Wolf J, Deibler K, Hogendorf WF, Bau S, Glendorf T, Stidsen CE, et al

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

The combination lacks specific safety and efficacy data and should be investigated with appropriate caution in controlled research settings

Summary: GLP-1 receptor agonists are not formally associated with leg cramps, but indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients