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GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA
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Our proposed receptor activation mechanism also suggests that the conformation of a GHSR ligand around the E124 3.33 -R283 6.55 salt bridge in the cavity II is an important structural determinant for ligand efficacy, providing a molecular foundation for designing novel ghrelin agonists
The titration schedule begins at 2.5 mg weekly for 4 weeks, then escalates through 5 mg, 7.5 mg, 10 mg, and 12.5 mg at 4-week intervals as tolerated, up to a maximum maintenance dose of 15 mg
