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Current treatments focus primarily on symptom management, as there are no FDA-approved medications for CFS/ME
& Accili, D
Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]
It is important to note that these medications are not intended for cosmetic weight loss or for individuals looking to lose a small amount of vanity weight. They are powerful metabolic tools designed for those whose weight is significantly impacting their long-term health and quality of life
The commentary authors also pointed to growing debate around the use of anti-obesity drugs in children over age 12, warning that wider use could potentially increase the number of rare eye complications seen later in life
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