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Originally developed for the treatment of type 2 diabetes mellitus, these agentsincluding semaglutide and tirzepatidehave demonstrated substantial efficacy in promoting weight loss and are increasingly reshaping therapeutic strategies for obesity, cardiovascular and kidney disease, and potentially substance use disorders.[1,2] Historically, paradigm-shifting therapeutics have periodically redefined clinical practice

Semaglutide is an injectable prescription medication for adults who are either overweight, obese, or otherwise struggle with chronic weight management

Blood pressure measurements were also performed daily at 8 am using a manual sphygmomanometer

The markings are simply a way to measure volume in very small, precise increments

However, this remains an interpretive inference because most studies do not experimentally separate these pathways