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It was developed in the early 1990s by the Danish pharmaceutical company Novo Nordisk, who were looking for a long-acting yet therapeutically effective treatment of type 2 diabetes [1]

Lower BMI thresholds (usually reduced by 2.5 kg/m2) should be used for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean ethnic backgrounds, NICE said

Additionally, ensuring adequate intake of essential cofactors like selenium (required for Glutathione Peroxidase activity) and B-vitamins (required for the glutathione reductase recycling process) can help optimize the body's ability to utilize the supplemented glutathione

The target is 25-35 grams per meal, distributed evenly throughout the day

Many patients notice reduced appetite, but early weeks often include GI side effects (like nausea or constipation), especially during dose increases