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We have no way of knowing whether these drugs, used so early in life for so long, could have unanticipated adverse effects, David Ludwig, an endocrinologist at Boston Childrens Hospital, told me
When you remove the dual-agonist support of Tirzepatide, your brains hunger signals can spike, often leading to rapid weight regain and metabolic fluctuations
A 2021 phase 2 trial published in The New England Journal of Medicine showed that semaglutide significantly improved NASH resolution but did not achieve statistically significant improvement in fibrosis stage compared to placebo
Therefore, development of incretin dual agonists such as the novel GCGR/GLP-1R dual agonist survodutide is an important step towards the more effective treatment of people with type 2 diabetes and obesity
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