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Lin, C.-C., Huang, Y.-C., Lee, W.-C

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Results maintenance requires ongoing or periodic use - stopping treatment leads to gradual regression over 2-6 months as new collagen formation stops and natural aging resumes

Temperature proves the dominant factor affecting degradation rates - every 10C increase doubles degradation speed, making refrigeration at 2-8C essential for all reconstituted solutions and beneficial for extending powder shelf life beyond basic 12-18 month refrigerated baseline