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H Ansar, Z Mazloom, F Kazemi, M Hejazi
The active ingredient in Jardiance is empagliflozin, and the active ingredient in Ozempic is semaglutide
10.1093/qjmed/hcn138
They also differ on the labelorforglipron approval came with post-marketing obligations and a caution around oral contraceptive effectiveness that oral semaglutide does not carry
And, as critics have pointed out over the years, by elevating just one, two, or at most, three researchers, the Nobels distort the history of science by personalizing discoveries that are truly made by groups of individuals. That reality hangs heavy especially over a decision about GLP-1 and other gut-hormone based drugs, given how much additional science had to be done to convert the hormones to effective, and then even more effective, drugs
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