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LCN2 can bind to siderophores and thereby lead to iron internalization via endocytosis or to the secretion of iron via endosome recycling thereby potentially enabling iron overload or iron deficiency ( LCN2 mRNA was reduced ( LCN2 mRNA expression in the bone marrow was associated with a favorable outcome especially in combination with wild-type FLT3 showing an enhanced apoptosis under hydrogen peroxide and cytarabine treatment whereas showing a protective effect under DFO treatment

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doi: 10.3389/fendo.2024.1400869 Received 14 March 2024 Accepted 28 June 2024 Published 11 July 2024 Volume 15 - 2024 Edited by Sijie Fang, Shanghai Jiao Tong University, China Reviewed by Yue Wang, First Affiliated Hospital of Xian Jiaotong University, China Lianqun Wu, Fudan University, China Updates Copyright 2024 Ma, Li, Lu and Li

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Therefore, we preformed DCFH-DA and C11-BODIPY staining followed by flow cytometry and found that WT ACTL6A reversed the increase in ROS levels (in cells treated with or without H 2 O 2 or both H 2 O 2 and NAC) and lipid peroxidation levels (in cells treated with or without erastin or both erastin and Fer-1), while ACTL6A HR-deleted mutant did not reverse these high levels (Fig