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In contrast, sustained or recurrent heat stress may induce Sertoli cell dysfunction and dedifferentiation, disrupt the bloodtestis barrier, and ultimately lead to persistent spermatogenic impairment or, in severe cases, irreversible infertility (Hu et al., 2021
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Two registered clinical trials exist: NCT02637284 (Phase I, sponsored by PharmaCotherapia d.o.o., a Croatian entity associated with the Sikiri group
Furthermore, certain chelators can disrupt iron-dependent neurophysiological processes, thereby further constraining their clinical applicability in NDDs (Marupudi and Xiong, 2024)
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