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They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies
Semaglutide is FDA-approved for weight management (Wegovy) and type 2 diabetes (Ozempic)
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A follow-up 2022 study examined NNMT inhibition combined with reduced calorie diet in DIO mice
Cure P, Pileggi A, Alejandro R
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