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In particular, the initial burst of superoxide that cannot be eliminated efficiently due to the inactivity of SOD1 is promptly buffered by the induction of GSH synthesis resulting in protection against oxidative stress and cell death
Rev Endocr Metab Disord
Therefore, we determined the structures of CAK-OTS964 and CDK2-cyclin A-OTS964, representing possible off-target complexes, to obtain further insight into OTS964 selectivity for CDK11 relative to other CDKs (Fig
New England Journal of Medicine , 2023
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