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256 Another study revealed elevated levels of p53 and proapoptotic proteins, including caspase-3, caspase-8, Bax, and Fas, in spinal motor neurons from individuals with ALS, whereas p53 levels were not altered in neurons of the motor cortex

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Indeed, because more than 100 proteins have been reported as TG2 substrates and because TG2 has broad substrate specificity, the GST tag could be crosslinked with a number of cellular proteins 21

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EXAMPLE 7: EFFECT OF DIFFERENT SURFACTANTS ON CO-FORMULATION PHYSICAL STABILITY This example shows the effect of different surfactants on the physical stability of otherwise identical cagrilintide and semaglutide co-formulations