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MOTS-c appears to be one of the most potent natural activators of this cascade [1]
A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone)
Watanabe, F., Hashizume, E., Chan, G
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