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Notably, the ongoing phase I/II trial of XNW5004, an EZH2 inhibitor, in combination with pembrolizumab (NCT06022757) exemplifies the effort to reprogram epigenetic states and restore ICB sensitivity in solid tumors resistant to conventional treatments

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It is not licensed by the MHRA or EMA in the UK and is unavailable through NHS prescribing pathways as of 2025