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She was prescribed a medication but did not make any diet or lifestyle changes, which she believes may have very slowly made my condition worse. She was later also diagnosed with connective tissue disease, mast cell activation syndrome (MCAS), Sjgrens syndrome and dysautonomia
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Controls were untreated, and showing 100% growth, while tests measured percentage decrease in bacterial growth with respect to this control
Firstly, it is indicated for obese adults, typically defined as having a Body Mass Index (BMI) of 30 or higher
Candidates for supervised discontinuation: Maintained goal weight on a stable dose for 12 or more months Lost weight primarily through combined medication and lifestyle change (not medication alone) Consume 1.2 to 1.6 g protein per kg body weight daily Perform resistance training 3 or more times per week Sleep 7 or more hours nightly with good sleep architecture Have a BMI at goal of 25 or higher (patients who drop into the low-normal range have less metabolic buffer) No history of binge eating disorder or significant emotional eating patterns Even with this profile, the SURMOUNT-4 data suggests that roughly half of patients will regain meaningful weight within 12 months of stopping (Aronne et al., JAMA 2024)
