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Avoid self-administering or altering the dosage without medical guidance
Epidemiology: High levels of vitamin B12 were found in: Causes: Excessive supplementation (a direct increase in plasma vitamin B12 by excess intake or administration) Increased release of vitamin B12 from tissue stores (liberation from an internal reservoir): Solid tumors (especially hepatic or hematologic malignancies) Liver metastases Increased binding proteins: 7 Excess production: Liver disease (e.g., hepatitis, cirrhosis, hepatocellular carcinoma) damaged hepatocytes release haptocorrin (transcobalamin I) and B12 into circulation Myeloproliferative disorders these increase granulocyte production, which leads to more haptocorrin (transcobalamin I/III), a B12-binding protein produced by proliferating myeloid cells
Important safety questions include product purity, dose accuracy, drug interactions, liver and kidney considerations, blood sugar changes, cardiovascular risk, pregnancy or breastfeeding status, and long-term exposure
10.1038/nrdp.2017.40 25 HigginsJ.GreenS
Your doctor will consider factors like your current B12 levels, weight, age, and health goals
