They act on the glucagon-like peptide-1 receptor, influencing insulin release, appetite, and possibly inflammation
Last, some evidence suggests that eating smaller, more frequent meals high in protein and fiber and low in fat can help manage gastrointestinal side effects
Furthermore, metformin was studied in combination with rosiglitazone in a randomized clinical trial (RCT) involving 137 patients with biopsy-proven NASH (Table 1)
Mitigation strategies include strict sun protection during treatment, using moderate rather than aggressive microneedling depths, incorporating niacinamide which helps prevent PIH, considering patch testing before full-face treatment, and being prepared to pause treatment if significant PIH develops
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