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The higher dose in the second half of the cycle is designed to reinforce the collagen synthesis, sirtuin activation, and anti-inflammatory pathways initiated in Phase 1
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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider
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