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The only tangentially relevant data comes from amphetamine studies where BPC-157 counteracted stereotypy, reduced heightened startle response, and prevented behavioral sensitization over 46 days of chronic amphetamine exposure
But it barely outperformed an existing drug
Both modifications are studied in vitro for the resistance they confer to exopeptidase cleavage and for their effect on measured peptide half-life in serum-stability assays
Diclofenac is widely distributed in the body so that systemic bioavailability is only 50%, found in the highest concentrations in liver and kidney
R., Nielsen, D
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