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This was confirmed in an additional cell line and with depletion of KG or suppression of KGDDs using knockdown/inhibition of IDH1, glutamine starvation, or succinate supplementation ( Fig
Introduction P|ESG Approach Impact Ambitions 40 2025 and 2026 Corporate Responsibility and P|ESG Ambitions 2025 Ambitions Status Description 2026 Ambitions Ascendis Pharma continues to grow with a Attraction, onboarding and Attraction, onboarding and retention of talent continued focus to attract and retain the right retention of talent to ensure we to ensure we have the right people to deliver on Ongoing talent to deliver on the Ascendis Pharma have the right people to deliver on our ambitions
ACS Chem Biol 12:19031912
6.2 Fatty acid metabolism and cardiovascular disease Inhibition of fatty acid oxidation in early HF is part of cardiac metabolic remodeling, but this inhibition progressively leads to mitochondrial dysfunction, which ultimately manifests itself in severe energy metabolism disturbances in advanced HF (139)
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