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Direct human clinical evidence remains insufficient
10.1016/j.jprot.2019.04.005 13 CerqueiraM.SchramaD.SilvaT
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Excessive NNMT activity can lead to a reduction in NAD+ and SAM levels
When it outpaces neutralization by enzymes like superoxide dismutase and small-molecule antioxidants such as glutathione, harm builds up
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