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00:04:03 Vickie Danaher For example, GLP-1 increases insulin secretion from the pancreas
However, recent Phase III data for the trifunctional GLP-1/GIP/Glucagon receptor agonist retatrutide show average weight loss of around 28.7%, significantly exceeding results from GLP-1 monotherapy
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NNMT is more active
A concrete example that clarifies this boundary is gastrin: multiple adequately powered human trials demonstrated that gastrin-based therapies failed to preserve beta-cell function in type 2 diabetes, and development was largely discontinued by approximately 2010
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