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Apart from promoting lipid synthesis and storage, PPAR can also upregulate the expression of ATGL and HSL [51]

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Berobenatide had a favorable risk-benefit profile with very few adverse events despite the fact that dose deescalation was not allowed in the study. The safety profile of berobenatide in VESPER-2 was consistent with the GLP-1 RA class, and no new safety signals were identified

They mimic the GLP-1 hormone released in the gut in response to eating