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In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)

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Contraindications and Safety Considerations That Affect Switching Decisions Before initiating tirzepatide or any incretin agent, screen for a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

When trial participants stopped tesamorelin, belly fat trended back toward pre-treatment levels, which suggests continued use is needed to keep results