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Rare Side Effects changes in blood sugar or early signs of insulin resistance numbness or tingling in the hands (carpal tunnellike symptoms) joint stiffness or discomfort sustained swelling that does not improve with rest or hydration Side effects often depend on which version is used

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Another study using NR supplementation showed that doses up to 1000 mg per day for 10 weeks were well tolerated in patients affected by mild cognitive impairments (MCI) 246

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