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( Canadian Journal of Anesthesia, 2025 ) review pharmacokinetic data for high-volume fascial plane blocks and show that while mean plasma concentrations of ropivacaine, levobupivacaine, and bupivacaine are usually below toxic thresholds, a consistent minority of patients exceed accepted toxicity levelsoften without overt LAST symptoms
Laufs et al., 2005
Most patients lose 5-10 pounds in the first month as appetite suppression takes effect and caloric intake decreases
Animals enrolled to the study had no significant difference in weight
Off-label prescriptions might not be covered
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