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Potential weaknesses of the LEADER model include that all patients were of high or higher CV risk than those in the SUSTAIN and PIONEER efficacy trials, which may have affected the analysis at the lower end of the continuum of risk
Biochem ., 1990 , 190 , 360
doi:10.1530/EJE-19-0167 Eng J et al
These include muscle weakness (difficulty climbing stairs, rising from a chair, or lifting objects), persistent muscle pain or tenderness, visible muscle swelling or changes in muscle appearance, or dark-colored urine, which may indicate rhabdomyolysisa rare but serious condition involving muscle breakdown
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