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Randomised, double-blind, placebo-controlled dose-escalation studies show that CJC-1295 produces sustained, dose-dependent increases in growth hormone and IGF-1, lasting several days after subcutaneous administration.[18] Ipamorelin has published human pharmacokinetic and pharmacodynamic data,[19] and has undergone a randomised phase-II study for postoperative ileus after bowel surgery.[20] But endocrine activity is not a dermatological outcome