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Furthermore, its tolerability profile, which includes weight gain, edema/fluid retention, fractures, and (rarely) bladder cancer in long-term use, could hinder its potential repositioning for depression [173]
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Some patients experience persistent nausea, vomiting, or constipation on tirzepatide that either doesn't improve with time or becomes incompatible with daily life
Left ventricular mass in chronic kidney disease and ESRD
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