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The major actions in phase I, carried out primarily by cytochrome P450 enzymes Include: Oxidation Hydration Reduction Hydrolysis1 The Next Step: Phase II Conjugation Phase II completes the process of taking fat-soluble toxins, estrogens, and other materials and turning them into inactive, water-soluble wastes for elimination

Data on patient-reported outcomes for individual GLP-1RAs indicate high treatment satisfaction rates with the long-acting agents (Table 3) [69,70,71,72,73,74], while dulaglutide was associated with higher adherence and persistence rates than exenatide QW and liraglutide [75]

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