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1) include (1) impaired chromosome integrity due to increased DNA damage (e.g., DNA double-strand breaks) [21], (2) weakened chromosome cohesion during chromosome segregation, causing a decrease in the level of chromosomal adhesin subunits, making oocytes susceptible to premature sister chromatid segregation in homologous chromosomes [22, 23], (3) dysfunction of spindle assembly checkpoints, which interferes with chromosome segregation, leading to premature chromosome segregation and chromosome mislocalisation [24], (4) meiotic recombination errors [25], and (5) telomere shortening leading to impaired chromosome integrity [25]
Ongoing research and investigational therapies, such as GIP/GLP-1/glucagon triple agonists, may inform future strategies for sustainable weight loss after discontinuation of weight loss pharmacotherapy
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Mona et al
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