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Un estudio de intervencin en 57 adultos sanos que fueron alimentados con dietas deficientes en colina en condiciones controladas encontr que el 77% de los hombres, el 80% de las mujeres posmenopusicas, y el 44% de las mujeres premenopusicas desarrollaron hgado graso, dao heptico, y/o dao muscular (17)