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For instance, tumor-associated macrophages (TAMs) exert a dominant inhibitory effect by significantly upregulating the expression of coinhibitory ligands such as PD-L1, thereby reducing the proportion of activated CD8 + T cells, suppressing their proliferation, and potentially inducing clonal anergy or deletion [113, 114]

Research has shown that glutathione is essential for neutralizing reactive oxygen species, supporting mitochondrial function, and maintaining cellular homeostasis

PMID: 111 RapizziE.PintonP.SzabadkaiG.WieckowskiM

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