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The major role of OCTN2 in carnitine absorption and tissue distribution is demonstrated by the existence of a human disease caused by inborn defects of the OCTN2 gene, namely PCD (Magoulas and El-Hattab, 2012)
Cell culture Clonal insulin-secreting BRIN-BD11 cells were maintained in RPMI 1640 medium containing 11.1 mM glucose, supplemented with 10% foetal bovine serum (FBS), 100 U/ml penicillin and 0.1 mg/ml streptomycin, pH 7.4, as described previously 45
Willard,Y
Similarly, 53 proteins were differentially expressed between PCC and uninfected individuals, while only 2 proteins differed between PCC and convalescent individuals (Fig
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