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This creates a devastating feedback loop: the lack of glutathione allows oxidative stress to run rampant, which further impairs the methylation cycle, which in turn prevents the production of more glutathione
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CRP is synthesized in smooth muscle cells of atherosclerotic lesions with active disease, foam cells, macrophages, lymphocytes, monocytes, and endothelial cells within the atherosclerotic plaque (166170)