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This points to the hypothesis that chronic hyperglycemia in diabetes, along with dysregulated central sensing of glucose concentrations in diabetics, may impair central transport of GLP-1 receptor agonist and explain the reduced efficacy for weight loss in type two diabetic patients. Geisler also discussed astrocytes
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(PubMed) Korotkov KV, Kumaraswamy E, Zhou Y, Hatfield DL, Gladyshev VN
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