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Compared to the active state, ECL1 moves toward helix I by 5 when measured at the N-terminal tip of the helix (C of Q211), and ECL1 residue W214 is reoriented ~180 o from an outside-facing position to a position pointing towards helix I
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However, if you are just starting to see grays or want to maintain your current color, supporting your antioxidant pathways is highly beneficial
The therapeutic window for inhibiting GGT as a cancer therapy is potentially large, as sustained inhibition of GGT activity did not induce any overt toxicities
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