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What the clinical evidence shows Several large, peer-reviewed studies have quantified the risk: The STEP 1 trial (NEJM, 2021): patients on high-dose semaglutide lost an average of 14.9% of their body weight over 68 weeks

Although its a good idea to monitor blood pressure when starting GLP-1 therapy, adjusting doses of these medications is rarely necessary

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Sensitivity analysis In the MDS-UPDRS Part III outcome domain, sensitivity analysis was intended to assess the robustness of the evidence

As we get older, our bodies produce less elastin, which is why skin can start to sag or take longer to snap back into place