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Retatrutide vs Tirzepatide: Next-Generation Weight Loss Medications Last Updated: February 2026 11 min read Key Takeaways Retatrutide is an investigational triple hormone agonist (GLP-1, GIP, and glucagon) showing 24% average weight loss in trials, while tirzepatide is FDA-approved with proven 21% weight loss

Choi emphasizes that thinking about or reverting to how your body used to function before taking one of these medicines can feel demoralizing or like a step back, especially if it brought positive changes to your life

Both have genuine limitations

They act on GLP-1 receptors to increase insulin production, slow gastric emptying, and help curb appetite

The software used for data processing was Analyst Software version 1.6.1 (AB Sciex) and MultiQuant Software version 2.0.2 (AB Sciex)