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Studies of APAP toxicity in hepatoma lines such as HepG2 exemplify this problem very well, since, although it is clear that APAP induces cytotoxicity in this cell line, the type and mechanism of toxicity is likely to be different from that of primary hepatocytes (McGill et al
These antioxidants can be derived from whole plants, plant extracts, or isolated components with complete phytochemical profiles
The risk is generally highest during the initial weeks of treatment and following dose increases, with symptoms often improving as the body adjusts to the medication
