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The copper binding is critical for biological activity it enables the peptide to modulate matrix metalloproteinases (MMPs), stimulate collagen synthesis, and provide antioxidant effects through coppers redox cycling

Insomnia affects a significant percentage of users, which is why morning dosing is standard

In March 2025, Roche entered into an outstanding licensing agreement and collaboration with Zealand Pharma for co-commercializing and co-developing petrelintide as a standalone therapy and a fixed-dose combination with Roches lead incretin asset CT-388

The published phase 2 trial studied five once-weekly doses: 0.3, 0.6, 1.2, 2.4 and 4.5 mg