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Pillar 6: Pioglitazone (PPAR-gamma agonist) Pioglitazone can improve insulin sensitivity partly by redistributing fat away from ectopic depots (liver and muscle) towards safer subcutaneous stores
157 Additionally, activation of GLP-1R promotes the AMPK pathway, which plays a vital role in the regulation of autophagy
Researchers purport that the metabolism of fat in muscle tissue, while up-regulating protein synthesis in muscle cells (individually), is considered to preserve glucose at the same time
In addition, the Alzheimers disease APPSWE/PS1E9 mouse model showed a reduction of neuroinflammation upon liraglutide treatment (Ventorp et al., 2017)
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