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1 Department of Paediatrics, University of Cambridge, Cambridge, UK, 2 NIHR Cambridge Biomedical Research Centre, Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK, 3 Institute of Metabolic Science and Department of Medicine, University of Cambridge, Cambridge, UK, 4 Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium