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This genetic variability in the underlying causes of obesity could be one explanation for why some people show a blunted response to these drugs
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"What kind of exercise actually helps here?" The 2024 JAMA Network Open trial found that GLP-1 medication combined with exercise preserved bone density, while GLP-1 medication alone was associated with bone density decline
The approval was based on data from the SUNSHINE and SUNRISE studies, which together showed that Cosentyx-treated patients achieved significantly higher rates of clinical response compared to placebo
