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Mesoporous silica nanoparticles have been utilized for selective internalization in tumor cells with endosomal escape, where the particles were decorated by self-immolative GSH-cleavable linkers as smart gatekeepers to prevent premature release 81
In other words, glutathione also protects the cell from the outside, not simply from ROS forming on the inside of the cell
Below, we explain how IM8 fared in each area
95% CI, 11.9 to 9.4)
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